Editor's Choice and featured articles
Microbleed and microinfarct detection in amyloid angiopathy: high-resolution MRI-histopathology study
Microbleeds and microinfarcts are key contributors to cognitive decline. Van Veluw et al. investigate the underlying pathology using ex vivo 7T MRI and detailed histological analysis of post-mortem tissue.
Cytoplasmic TDP-43 aggregation is a hallmark of ALS and FTLD. Iguchi et al. present data implicating exosomes in both the propagation and clearance of TDP-43 aggregates.
Wrasidlo et al. show that a novel compound designed in silico — NPT100-18A — reduces α-synuclein toxicity by altering the interaction of α-synuclein with the cell membrane.
It is often said that Shakespeare was a psychoanalyst 300 years before Freud. Drawing on examples from Macbeth to King Lear, Robert McCrum argues that Shakespeare was also something of a proto-neurologist.
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